Typing this in a non-qwerty layout on a new ergonomic keyboard. Learning the alphabet anew is of course a challenge, as is getting to know the keys themselves. My pinkies want to rest on the upper row, and the upper thumb keys are hard to reach; I think both these problems could be lessened if the palm rest were higher on the pinkie side.
When I started shopping for a new keyboard, I found quite a rabbit-hole of enthusiasts. The cool kids use home-built boards of only 34 or 36 keys.